Effects of manidipine vs. amlodipine on intrarenal haemodynamics in patients with arterial hypertension.

ABSTRACT:

Aims

Intraglomerular pressure is one of the main drivers of progression of renal failure. Experimental data suggest that there are important differences between calcium channel blockers (CCBs) in their renal haemodynamic effects: manidipine reduces, whereas amlodipine increases intraglomerular pressure. The aim of this study was to investigate the effects of manidipine and amlodipine treatment on intragomerular pressure (P(glom)) in patients with mild to moderate essential hypertension.

Methods

In this randomized, double-blind, parallel group study, hypertensive patients were randomly assigned to receive manidipine 20 mg (n = 54) or amlodipine 10 mg (n = 50) for 4 weeks. Renal plasma flow (RPF) and glomerular filtration rate (GFR) were determined by constant-infusion input-c

SUBMITTER: Ott C 

PROVIDER: S-EPMC3555052 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature