Exenatide once weekly: sustained improvement in glycemic control and cardiometabolic measures through 3 years.

ABSTRACT:

Background

Type 2 diabetes mellitus is a progressive metabolic disease necessitating therapies with sustained efficacy and safety over time. Exenatide once weekly (ExQW), an extended-release formulation of the glucagon-like peptide-1 receptor agonist exenatide, has demonstrated improvements in glycemic and cardiometabolic measures from 30 weeks to 2 years of treatment. Here, the efficacy and safety of treatment with ExQW for 3 years are described.

Methods

Patients were initially randomized to receive either ExQW (2 mg) or exenatide twice daily for 30 weeks. Following the initial 30 weeks, all patients were treated with ExQW in an open-label extension. Analyses of primary glycemic endpoints, beta-cell function, and cardiometabolic measures were assessed for patients who compl

SUBMITTER: Macconell L 

PROVIDER: S-EPMC3555554 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature