Novel protein therapeutics for systolic heart failure: chronic subcutaneous B-type natriuretic peptide.

ABSTRACT:

Objectives

The purpose of the present study was to translate our laboratory investigations to establish safety and efficacy of 8 weeks of chronic SC B-type natriuretic peptide (BNP) administration in human Stage C heart failure (HF).

Background

B-Type natriuretic peptide is a cardiac hormone with vasodilating, natriuretic, renin-angiotensin inhibiting, and lusitropic properties. We have previously demonstrated that chronic cardiac hormone replacement with subcutaneous (SC) administration of BNP in experimental HF resulted in improved cardiovascular function.

Methods

We performed a randomized double-blind placebo-controlled proof of concept study comparing 8 weeks of SC BNP (10 μg/kg bid) (n = 20) with placebo (n = 20) in patients with ejection fraction <35% and New Yo

SUBMITTER: Chen HH 

PROVIDER: S-EPMC3555560 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature