Proline: the distribution, frequency, positioning, and common functional roles of proline and polyproline sequences in the human proteome.

ABSTRACT: Proline is an anomalous amino acid. Its nitrogen atom is covalently locked within a ring, thus it is the only proteinogenic amino acid with a constrained phi angle. Sequences of three consecutive prolines can fold into polyproline helices, structures that join alpha helices and beta pleats as architectural motifs in protein configuration. Triproline helices are participants in protein-protein signaling interactions. Longer spans of repeat prolines also occur, containing as many as 27 consecutive proline residues. Little is known about the frequency, positioning, and functional significance of these proline sequences. Therefore we have undertaken a systematic bioinformatics study of proline residues in proteins. We analyzed the distribution and frequency of 687,434 proline residues among 18

SUBMITTER: Morgan AA 

PROVIDER: S-EPMC3556072 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature