Evolution at increased error rate leads to the coexistence of multiple adaptive pathways in an RNA virus.

ABSTRACT:

Background

When beneficial mutations present in different genomes spread simultaneously in an asexual population, their fixation can be delayed due to competition among them. This interference among mutations is mainly determined by the rate of beneficial mutations, which in turn depends on the population size, the total error rate, and the degree of adaptation of the population. RNA viruses, with their large population sizes and high error rates, are good candidates to present a great extent of interference. To test this hypothesis, in the current study we have investigated whether competition among beneficial mutations was responsible for the prolonged presence of polymorphisms in the mutant spectrum of an RNA virus, the bacteriophage Qβ, evolved during a large number of generati

SUBMITTER: Cabanillas L 

PROVIDER: S-EPMC3556134 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature