Ontology highlight
ABSTRACT:
SUBMITTER: Lee SW
PROVIDER: S-EPMC3556199 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Brain, behavior, and immunity 20121003
Cranial irradiation for the treatment of brain tumors causes a delayed and progressive cognitive decline that is pronounced in young patients. Dysregulation of neural stem and progenitor cells is thought to contribute to these effects by altering early childhood brain development. Earlier work has shown that irradiation creates a chronic neuroinflammatory state that severely and selectively impairs postnatal and adult neurogenesis. Here we show that irradiation induces a transient non-classical ...[more]