Changes in proteomic profiles in different prostate lobes of male rats throughout growth and development and aging stages of the life span.

ABSTRACT:

Background

Aging-related changes in important cellular pathways in the prostate may promote a permissive environment for an increased risk for prostatic disease development such as prostate cancer. Our objectives were to examine for such changes, by systematically determining the effects of growth and development and aging on proteomic profiles in different lobes of the rat prostate.

Methods

Prostate lobes (dorsolateral lobe, DL and ventral lobe, VL) were obtained from male Fisher rats of various ages representing young (4 months), mature (12 months), old (18 months), and very old (24 months). Differentially expressed proteins between age groups in each lobe were identified using a proteomic approach, isobaric Tags for Relative and Absolute Quantitation (iTRAQ). Select chang

SUBMITTER: Das A 

PROVIDER: S-EPMC3556222 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature