Structure of the type IV secretion system in different strains of Anaplasma phagocytophilum.

ABSTRACT:

Background

Anaplasma phagocytophilum is an intracellular organism in the Order Rickettsiales that infects diverse animal species and is causing an emerging disease in humans, dogs and horses. Different strains have very different cell tropisms and virulence. For example, in the U.S., strains have been described that infect ruminants but not dogs or rodents. An intriguing question is how the strains of A. phagocytophilum differ and what different genome loci are involved in cell tropisms and/or virulence. Type IV secretion systems (T4SS) are responsible for translocation of substrates across the cell membrane by mechanisms that require contact with the recipient cell. They are especially important in organisms such as the Rickettsiales which require T4SS to aid colonization and surv

SUBMITTER: Al-Khedery B 

PROVIDER: S-EPMC3556328 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature