Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development.

ABSTRACT: The stratum corneum is composed of protein-enriched corneocytes embedded in an intercellular matrix of nonpolar lipids organized as lamellar layers and giving rise to epidermal permeability barrier (EPB). EPB defects have an important role in the pathophysiology of skin diseases such as eczema. The transcriptional control of skin lipid metabolism is poorly understood. We have discovered that mice lacking transcription factor COUP-TF-interacting protein 2 (Ctip2) exhibit EPB defects including altered keratinocyte terminal differentiation, delayed skin barrier development, and interrupted neutral lipid distribution in the epidermis. Here we adapted a targeted lipidomic approach using mass spectrometry and have determined that Ctip2(-/-) mice (germline deletion of the Ctip2 gene) display alte

SUBMITTER: Wang Z 

PROVIDER: S-EPMC3556343 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature