Tissue-specific responses to aberrant FGF signaling in complex head phenotypes.

ABSTRACT:

Background

The role of fibroblast growth factor and receptor (FGF/FGFR) signaling in bone development is well studied, partly because mutations in FGFRs cause human diseases of achondroplasia and FGFR-related craniosynostosis syndromes including Crouzon syndrome. The FGFR2c C342Y mutation is a frequent cause of Crouzon syndrome, characterized by premature cranial vault suture closure, midfacial deficiency, and neurocranial dysmorphology. Here, using newborn Fgfr2c(C342Y/+) Crouzon syndrome mice, we tested whether the phenotypic effects of this mutation go beyond the skeletal tissues of the skull, altering the development of other non-skeletal head tissues including the brain, the eyes, the nasopharynx, and the inner ears.

Results

Quantitative analysis of 3D multimodal imagin

SUBMITTER: Martinez-Abadias N 

PROVIDER: S-EPMC3556393 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature