Evaluation of an amniotic membrane-collagen dermal substitute in the management of full-thickness skin defects in a pig.

ABSTRACT:

Background

To minimize the inflammatory reaction and improve healing, a new modified dermal substitute composed of an atelocollagen, chondroitin-6-sulfate, and amniotic membrane (AM) was applied to full-thickness skin defects in a pig. Atelocollagen was extracted from bovine skin, and two modified dermal substitutes were generated according to the cross-linking type.

Methods

The AM-collagen dermal substitutes were characterized and compared with currently used dermal substitutes in a pig skin defect model. There were five experimental groups: dehydrothermal (DHT) cross-linking atelocollagen with the AM on the top (AM-DHT), DHT and chemical cross-linking atelocollagen with the AM on the top (AM-DHT/chemical), Terudermis, Integra, and AlloDerm. After 3×3 cm full-thickness skin

SUBMITTER: Kim H 

PROVIDER: S-EPMC3556528 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature