A FOXO3-IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses.

ABSTRACT: Antiviral responses must be tightly regulated to defend rapidly against infection while minimizing inflammatory damage. Type 1 interferons (IFN-I) are crucial mediators of antiviral responses and their transcription is regulated by a variety of transcription factors; principal among these is the family of interferon regulatory factors (IRFs). The IRF gene regulatory networks are complex and contain multiple feedback loops. The tools of systems biology are well suited to elucidate the complex interactions that give rise to precise coordination of the interferon response. Here we have used an unbiased systems approach to predict that a member of the forkhead family of transcription factors, FOXO3, is a negative regulator of a subset of antiviral genes. This prediction was validated using mac

SUBMITTER: Litvak V 

PROVIDER: S-EPMC3556990 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature