Histone methyltransferase MLL3 contributes to genome-scale circadian transcription.

ABSTRACT: Daily cyclical expression of thousands of genes in tissues such as the liver is orchestrated by the molecular circadian clock, the disruption of which is implicated in metabolic disorders and cancer. Although we understand much about the circadian transcription factors that can switch gene expression on and off, it is still unclear how global changes in rhythmic transcription are controlled at the genomic level. Here, we demonstrate circadian modification of an activating histone mark at a significant proportion of gene loci that undergo daily transcription, implicating widespread epigenetic modification as a key node regulated by the clockwork. Furthermore, we identify the histone-remodelling enzyme mixed lineage leukemia (MLL)3 as a clock-controlled factor that is able to directly and in

SUBMITTER: Valekunja UK 

PROVIDER: S-EPMC3557088 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature