Validation of MIMGO: a method to identify differentially expressed GO terms in a microarray dataset.

ABSTRACT:

Background

We previously proposed an algorithm for the identification of GO terms that commonly annotate genes whose expression is upregulated or downregulated in some microarray data compared with in other microarray data. We call these "differentially expressed GO terms" and have named the algorithm "matrix-assisted identification method of differentially expressed GO terms" (MIMGO). MIMGO can also identify microarray data in which genes annotated with a differentially expressed GO term are upregulated or downregulated. However, MIMGO has not yet been validated on a real microarray dataset using all available GO terms.

Findings

We combined Gene Set Enrichment Analysis (GSEA) with MIMGO to identify differentially expressed GO terms in a yeast cell cycle microarray dataset.

SUBMITTER: Yamada Y 

PROVIDER: S-EPMC3557167 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature