New measurement methods of network robustness and response ability via microarray data.

ABSTRACT: "Robustness", the network ability to maintain systematic performance in the face of intrinsic perturbations, and "response ability", the network ability to respond to external stimuli or transduce them to downstream regulators, are two important complementary system characteristics that must be considered when discussing biological system performance. However, at present, these features cannot be measured directly for all network components in an experimental procedure. Therefore, we present two novel systematic measurement methods--Network Robustness Measurement (NRM) and Response Ability Measurement (RAM)--to estimate the network robustness and response ability of a gene regulatory network (GRN) or protein-protein interaction network (PPIN) based on the dynamic network model constructed

SUBMITTER: Tu CT 

PROVIDER: S-EPMC3557243 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature