Hyaluronic acid induces activation of the κ-opioid receptor.

ABSTRACT:

Introduction

Nociceptive pain is one of the most common types of pain that originates from an injury involving nociceptors. Approximately 60% of the knee joint innervations are classified as nociceptive. The specific biological mechanism underlying the regulation of nociceptors is relevant for the treatment of symptoms affecting the knee joint. Intra-articular administration of exogenous hyaluronic acid (HA) in patients with osteoarthritis (OA) appears to be particularly effective in reducing pain and improving patient function.

Methods

We performed an in vitro study conducted in CHO cells that expressed a panel of opioid receptors and in primary rat dorsal root ganglion (DRG) neurons to determine if HA induces the activation of opioid peptide receptors (OPr) using both aequ

SUBMITTER: Zavan B 

PROVIDER: S-EPMC3557250 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature