Ontology highlight
ABSTRACT:
SUBMITTER: Rudin CM
PROVIDER: S-EPMC3557461 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Nature genetics 20120902 10
Small-cell lung cancer (SCLC) is an exceptionally aggressive disease with poor prognosis. Here, we obtained exome, transcriptome and copy-number alteration data from approximately 53 samples consisting of 36 primary human SCLC and normal tissue pairs and 17 matched SCLC and lymphoblastoid cell lines. We also obtained data for 4 primary tumors and 23 SCLC cell lines. We identified 22 significantly mutated genes in SCLC, including genes encoding kinases, G protein-coupled receptors and chromatin-m ...[more]