Pro-inflammatory chemokine C-C motif ligand 16 (CCL-16) dysregulation in irritable bowel syndrome (IBS): a pilot study.

ABSTRACT:

Background

Irritable bowel syndrome (IBS) is a serious health problem that affects an estimated 10-15% of people worldwide and has economic consequences in the United States of over $30 billion annually. In the US, IBS affects all races and both sexes, with more females than males (2:1) reporting symptoms consistent with IBS. Although the etiology of this functional gastrointestinal disorder is unknown, literature suggests that a subclinical inflammatory component has a role in the etiologic mechanisms underlying IBS. The aim of this study was to evaluate the gene expression of inflammatory biomarkers in patients with and without IBS and among different IBS phenotypes.

Methods

Irritable bowel syndrome patients (n=12) that met Rome III Criteria for IBS longer than 6months wer

SUBMITTER: Del Valle-Pinero AY 

PROVIDER: S-EPMC3557463 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature