Astrocyte and macrophage regulation of YKL-40 expression and cellular response in neuroinflammation.

ABSTRACT: Numerous inflammatory conditions are associated with elevated YKL-40 expression by infiltrating macrophages. Thus, we were surprised to observe minimal macrophage and abundant astrocyte expression of YKL-40 in neuroinflammatory conditions. The aims of the current study were to better delineate this discrepancy, characterize the factors that regulate YKL-40 expression in macrophages and astrocytes and study whether YKL-40 expression correlates with cell morphology and/or activation state. In vitro, macrophages expressed high levels of YKL-40 that was induced by classical activation and inhibited by alternative activation. Cytokines released from macrophages induced YKL-40 transcription in astrocytes that was accompanied by morphological changes and altered astrocytic motility. Because cocul

SUBMITTER: Bonneh-Barkay D 

PROVIDER: S-EPMC3557465 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature