Gene products of the embedded m41/m41.1 locus of murine cytomegalovirus differentially influence replication and pathogenesis.
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ABSTRACT:
SUBMITTER: Crosby LN
PROVIDER: S-EPMC3557549 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
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Gene products of the embedded m41/m41.1 locus of murine cytomegalovirus differentially influence replication and pathogenesis.
Crosby Lynsey N LN McCormick A Louise AL Mocarski Edward S ES
Virology 20130105 2
Cytomegaloviruses utilize overlapping and embedded reading frames as a way to efficiently package and express all genes necessary to carry out a complex lifecycle. Murine cytomegalovirus encodes a mitochondrial-localized inhibitor of Bak oligomerization (vIBO) from m41.1, a reading frame that is embedded within the m41 gene. The m41.1-encoded mitochondrial protein and m41-encoded Golgi-localized protein have both been implicated in cell death suppression; however, their contribution to viral inf ...[more]
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