Frontal function and executive processing in older adults: process and region specific age-related longitudinal functional changes.

ABSTRACT: Longitudinal studies on aging brain function have shown declines in frontal activity as opposed to the over-recruitment shown in cross-sectional studies. Such mixed findings suggest that age-related changes in frontal activity may be process- and region-specific, having varied associations across different frontal regions involved in distinct cognitive processes, rather than generalized across the frontal cortex. Using data from the Baltimore Longitudinal Study of Aging (BLSA), we examined individual differences through cross-sectional associations at baseline evaluation and longitudinal changes in regional cerebral blood flow (rCBF) in relation to different executive abilities in cognitively normal older adults. We found that, at baseline, greater rCBF in middle frontal regions correlated

SUBMITTER: Goh JO 

PROVIDER: S-EPMC3557589 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature