Nutrients related to one-carbon metabolism and risk of renal cell cancer.

ABSTRACT:

Purpose

Folate, vitamins B6 and B12, methionine, choline, and betaine are nutrients related to one-carbon metabolism and have been hypothesized to decrease cancer risk. Few studies have evaluated dietary intakes of these nutrients in relation to renal cell cancer (RCC).

Methods

We conducted prospective follow-up studies of women in the Nurses' Health Study and men in the Health Professionals Follow-up Study. Diet was assessed repeatedly using a validated semi-quantitative food-frequency questionnaire in both studies.

Results

During follow-up of 24 years among 77,208 women (918,891 person-years) and 22 years among 47,886 men (1,731,752 person-years), we accrued 436 cases of RCC (225 women and 211 men). Intakes of folate, vitamins B6 and B12, methionine, and betaine wer

SUBMITTER: Cho E 

PROVIDER: S-EPMC3557764 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature