PBX/extradenticle is required to re-establish axial structures and polarity during planarian regeneration.

ABSTRACT: Recent advances in a number of systems suggest many genes involved in orchestrating regeneration are redeployed from similar processes in development, with others being novel to the regeneration process in particular lineages. Of particular importance will be understanding the architecture of regenerative genetic regulatory networks and whether they are conserved across broad phylogenetic distances. Here, we describe the role of the conserved TALE class protein PBX/Extradenticle in planarians, a representative member of the Lophotrocozoa. PBX/Extradenticle proteins play central roles in both embryonic and post-embryonic developmental patterning in both vertebrates and insects, and we demonstrate a broad requirement during planarian regeneration. We observe that Smed-pbx has pleiotropic fun

SUBMITTER: Blassberg RA 

PROVIDER: S-EPMC3557773 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature