The microRNA miR-7 regulates Tramtrack69 in a developmental switch in Drosophila follicle cells.

ABSTRACT: Development in multicellular organisms includes both small incremental changes and major switches of cell differentiation and proliferation status. During Drosophila oogenesis, the follicular epithelial cells undergo two major developmental switches that cause global changes in the cell-cycle program. One, the switch from the endoreplication cycle to a gene-amplification phase, during which special genomic regions undergo repeated site-specific replication, is attributed to Notch downregulation, ecdysone signaling activation and upregulation of the zinc-finger protein Tramtrack69 (Ttk69). Here, we report that the microRNA miR-7 exerts an additional layer of regulation in this developmental switch by regulating Ttk69 transcripts. miR-7 recognizes the 3' UTR of ttk69 transcripts and regulate

SUBMITTER: Huang YC 

PROVIDER: S-EPMC3557780 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature