Specific patterns of allergic sensitization in early childhood and asthma & rhinitis risk.

ABSTRACT:

Background

Specific patterns of allergic sensitization as well as quantification of the in vitro IgE response in early life may provide relevant clinical insight into future rhinitis and asthma risk.

Objective

To define relationships among established sensitization to particular aeroallergens, quantitative analyses of allergen-specific IgE levels, pet exposure and sensitization, and asthma and rhinitis risk.

Methods

Children at high-risk for the development of asthma and allergic diseases were enrolled at birth into the Childhood Origins of ASThma (COAST) study. Allergen-specific IgE was assessed at ages 1, 3, 6, and 9 years by fluoroenzyme immunoassay (Unicap(®) 100; Pharmacia Diagnostics). Current asthma and rhinitis were diagnosed at age 6 and 8 years.

Results<

SUBMITTER: Stoltz DJ 

PROVIDER: S-EPMC3557802 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature