Multiparametric MRI and CT models of infarct core and favorable penumbral imaging patterns in acute ischemic stroke.

ABSTRACT:

Background and purpose

Objective imaging methods to identify optimal candidates for late recanalization therapies are needed. The study goals were (1) to develop magnetic resonance imaging (MRI) and computed tomography (CT) multiparametric, voxel-based predictive models of infarct core and penumbra in acute ischemic stroke patients, and (2) to develop patient-level imaging criteria for favorable penumbral pattern based on good clinical outcome in response to successful recanalization.

Methods

An analysis of imaging and clinical data was performed on 2 cohorts of patients (one screened with CT, the other with MRI) who underwent successful treatment for large vessel, anterior circulation stroke. Subjects were divided 2:1 into derivation and validation cohorts. Pretreatment ima

SUBMITTER: Kidwell CS 

PROVIDER: S-EPMC3558033 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature