Breast cancer: assessing response to neoadjuvant chemotherapy by using US-guided near-infrared tomography.

ABSTRACT:

Purpose

To assess initial breast tumor hemoglobin (Hb) content before the initiation of neoadjuvant chemotherapy, monitor the Hb changes at the end of each treatment cycle, and correlate these findings with tumor pathologic response.

Materials and methods

The HIPAA-compliant study protocol was approved by the institutional review boards of both institutions. Written informed consent was obtained from all patients. Patients who were eligible for neoadjuvant chemotherapy were recruited between December 2007 and May 2011, and their tumor Hb content was assessed by using a near-infrared imager coupled with an ultrasonography (US) system. Thirty-two women (mean age, 48 years; range, 32-82 years) were imaged before treatment, at the end of every treatment cycle, and before definit

SUBMITTER: Zhu Q 

PROVIDER: S-EPMC3558877 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature