Endocrine regulation of spermatogonial stem cells in the seminiferous epithelium of adult mice.

ABSTRACT: A balance between self-renewal and differentiation of spermatogonial stem cells (SSCs) is required to maintain sperm production throughout male life. The seminiferous epithelium is organized into stages of spermatogenesis based on the complement of germ cell types within a tubular section of the testis. The stages exist in close physical proximity and foster diverse phases of germ cell development despite exposure to a similar endocrine milieu that supports coordinated spermatogenesis. The objective of the current study was to identify the population dynamics of SSCs in vivo. We hypothesized that SSC populations and their niches are specifically distributed across the mature seminiferous epithelium in the mouse testis. To test this hypothesis, we conducted stem cell transplantation of germ

SUBMITTER: Caires KC 

PROVIDER: S-EPMC3559217 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature