TGF-β/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos.

ABSTRACT: The Transforming Growth Factor-β (TGF-β) signaling pathway is one of the major pathways essential for normal embryonic development and tissue homeostasis, with anti-tumor but also pro-metastatic properties in cancer. This pathway directly regulates several target genes that mediate its downstream functions, however very few microRNAs (miRNAs) have been identified as targets. miRNAs are modulators of gene expression with essential roles in development and a clear association with diseases including cancer. Little is known about the transcriptional regulation of the primary transcripts (pri-miRNA, pri-miR) from which several mature miRNAs are often derived. Here we present the identification of miRNAs regulated by TGF-β signaling in mouse embryonic stem (ES) cells and early embryos. We used

SUBMITTER: Redshaw N 

PROVIDER: S-EPMC3559380 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature