Transcriptional regulation of VEGFA by the endoplasmic reticulum stress transducer OASIS in ARPE-19 cells.

ABSTRACT:

Background

Vascular endothelial growth factor-A (VEGFA) is the main mediator of angiogenesis. Angiogenesis plays important roles not only in many physiological processes, but also in the pathophysiology of many diseases. VEGFA is one of the therapeutic targets of treatment for ocular diseases with neovascularization. Therefore, elucidation of the regulatory mechanisms for VEGFA expression is important for the development of pharmaceutical drugs. Recent studies have demonstrated that the unfolded protein response is involved in the transcriptional regulation of VEGFA. However, the precise regulation of VEGFA in the human retina is not fully understood.

Principal findings

When human retinal pigment epithelial cells, ARPE-19, were exposed to endoplasmic reticulum stressors, VEG

SUBMITTER: Miyagi H 

PROVIDER: S-EPMC3559390 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature