The evolution of vertebrate somatostatin receptors and their gene regions involves extensive chromosomal rearrangements.

ABSTRACT:

Background

Somatostatin and its related neuroendocrine peptides have a wide variety of physiological functions that are mediated by five somatostatin receptors with gene names SSTR1-5 in mammals. To resolve their evolution in vertebrates we have investigated the SSTR genes and a large number of adjacent gene families by phylogeny and conserved synteny analyses in a broad range of vertebrate species.

Results

We find that the SSTRs form two families that belong to distinct paralogons. We observe not only chromosomal similarities reflecting the paralogy relationships between the SSTR-bearing chromosome regions, but also extensive rearrangements between these regions in teleost fish genomes, including fusions and translocations followed by reshuffling through intrachromosomal re

SUBMITTER: Ocampo Daza D 

PROVIDER: S-EPMC3560075 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature