Association between XRCC1 polymorphism 399 G->A and glioma among Caucasians: a systematic review and meta-analysis.

ABSTRACT:

Background

The x-ray cross complementing group 1 gene (XRCC1) is crucial to proper repair of DNA damage such as single-strand DNA breaks. A non-synonymous polymorphism in XRCC1, 399 G → A, has been shown to reduce effectiveness of such DNA repair and has been associated with the risk of certain cancers. The known risk for glioma from high dose ionizing radiation makes associations between this polymorphism and glioma of particular interest.

Methods

A systematic literature review and meta-analysis was conducted to explore the association between XRCC1 399 G → A and glioma. Subgroup analyses by grade, gender, genotyping method, country in which study was conducted, and study size were conducted when data were available and validity of the results were assessed by influence ana

SUBMITTER: Jacobs DI 

PROVIDER: S-EPMC3560258 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature