RNA-seq analysis of synovial fibroblasts brings new insights into rheumatoid arthritis.

ABSTRACT:

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Background

Rheumatoid arthritis (RA) is a chronic autoimmune-disease of unknown origin that primarily affects the joints and ultimately leads to their destruction. Growing evidence suggests that synvovial fibroblasts play important roles in the initiation and the perpetuation of RA but underlying molecular mechanisms are not understood fully. In the present study, Illumina RNA sequencing was used to profile two human normal control and two rheumatoid arthritis synvovial fibroblasts (RASFs) transcriptomes to gain insights into the roles of synvovial fibroblasts in RA.

Results

We found that besides known inflammatory and immune responses, other novel dysregulated networks and pathways such as Cell Morphology, Cell-To-Cell Signaling and Interaction, Cellular

SUBMITTER: Heruth DP 

PROVIDER: S-EPMC3560277 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature