Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.

ABSTRACT:

Background

The PR interval, as measured by the resting, standard 12-lead ECG, reflects the duration of atrial/atrioventricular nodal depolarization. Substantial evidence exists for a genetic contribution to PR, including genome-wide association studies that have identified common genetic variants at 9 loci influencing PR in populations of European and Asian descent. However, few studies have examined loci associated with PR in African Americans.

Methods and results

We present results from the largest genome-wide association study to date of PR in 13 415 adults of African descent from 10 cohorts. We tested for association between PR (ms) and ≈2.8 million genotyped and imputed single-nucleotide polymorphisms. Imputation was performed using HapMap 2 YRI and CEU panels. Study-sp

SUBMITTER: Butler AM 

PROVIDER: S-EPMC3560365 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature