A proteomic study of potential VEGF-C-associated proteins in bladder cancer T24 cells.

ABSTRACT:

Background

Overexpression of vascular endothelial growth factor-C (VEGF-C) has been found to play an important role in malignant progression of various cancer cells, in addition to lymphangiogenesis. However, the mechanisms involved are still largely unknown. Our early research has confirmed that the expression of VEGF-C in bladder cancer was markedly higher than that in normal bladder tissues. VEGF-C can also obviously promote proliferation and invasion of bladder cancer T24 cells. In the present work, we attempted to use proteomic analysis to screen out potential VEGF-C-associated proteins involved in malignant progression of the bladder cancer T24 cells.

Material/methods

Lentivirus vector-based RNA interference (RNAi) was employed to diminish VEGF-C expression of bladder

SUBMITTER: Zhang HH 

PROVIDER: S-EPMC3560612 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature