Genomic insights into the atopic eczema-associated skin commensal yeast Malassezia sympodialis.

ABSTRACT:

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Malassezia commensal yeasts are associated with a number of skin disorders, such as atopic eczema/dermatitis and dandruff, and they also can cause systemic infections. Here we describe the 7.67-Mbp genome of Malassezia sympodialis, a species associated with atopic eczema, and contrast its genome repertoire with that of Malassezia globosa, associated with dandruff, as well as those of other closely related fungi. Ninety percent of the predicted M. sympodialis protein coding genes were experimentally verified by mass spectrometry at the protein level. We identified a relatively limited number of genes related to lipid biosynthesis, and both species lack the fatty acid synthase gene, in line with the known requirement of these yeasts to assimilate lipids from the host. Mala

SUBMITTER: Gioti A 

PROVIDER: S-EPMC3560662 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature