Specific genes involved in synthesis and editing of heparan sulfate proteoglycans show altered expression patterns in breast cancer.

ABSTRACT:

Background

The expression of a specific set of genes controls the different structures of heparan sulfate proteoglycans (HSPGs), which are involved in the growth, invasion and metastatic properties of cancerous cells. The purpose of this study is to increase knowledge of HSPG alterations in breast cancer.

Methods

Twenty-three infiltrating ductal adenocarcinomas (IDCs), both metastatic and non-metastatic were studied. A transcriptomic approach to the structure of heparan sulfate (HS) chains was used, employing qPCR to analyze both the expression of the enzymes involved in their biosynthesis and editing, as well as the proteoglycan core proteins. Since some of these proteoglycans can also carry chondroitin sulfate chains, we extended the study to include the genes involved in

SUBMITTER: Fernandez-Vega I 

PROVIDER: S-EPMC3561094 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature