The meiotic nuclear lamina regulates chromosome dynamics and promotes efficient homologous recombination in the mouse.

ABSTRACT: The nuclear lamina is the structural scaffold of the nuclear envelope and is well known for its central role in nuclear organization and maintaining nuclear stability and shape. In the past, a number of severe human disorders have been identified to be associated with mutations in lamins. Extensive research on this topic has provided novel important clues about nuclear lamina function. These studies have contributed to the knowledge that the lamina constitutes a complex multifunctional platform combining both structural and regulatory functions. Here, we report that, in addition to the previously demonstrated significance for somatic cell differentiation and maintenance, the nuclear lamina is also an essential determinant for germ cell development. Both male and female mice lacking the sho

SUBMITTER: Link J 

PROVIDER: S-EPMC3561109 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature