Gains of ubiquitylation sites in highly conserved proteins in the human lineage.

ABSTRACT:

Background

Post-translational modification of lysine residues of specific proteins by ubiquitin modulates the degradation, localization, and activity of these target proteins. Here, we identified gains of ubiquitylation sites in highly conserved regions of human proteins that occurred during human evolution.

Results

We analyzed human ubiquitylation site data and multiple alignments of orthologous mammalian proteins including those from humans, primates, other placental mammals, opossum, and platypus. In our analysis, we identified 281 ubiquitylation sites in 252 proteins that first appeared along the human lineage during primate evolution: one protein had four novel sites; four proteins had three sites each; 18 proteins had two sites each; and the remaining 229 proteins had

SUBMITTER: Kim DS 

PROVIDER: S-EPMC3561281 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature