Boosting for detection of gene-environment interactions.

ABSTRACT: In genetic association studies, it is typically thought that genetic variants and environmental variables jointly will explain more of the inheritance of a phenotype than either of these two components separately. Traditional methods to identify gene-environment interactions typically consider only one measured environmental variable at a time. However, in practice, multiple environmental factors may each be imprecise surrogates for the underlying physiological process that actually interacts with the genetic factors. In this paper, we develop a variant of L(2) boosting that is specifically designed to identify combinations of environmental variables that jointly modify the effect of a gene on a phenotype. Because the effect modifiers might have a small signal compared with the main effect

SUBMITTER: Pashova H 

PROVIDER: S-EPMC3561470 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature