A methamphetamine vaccine attenuates methamphetamine-induced disruptions in thermoregulation and activity in rats.

ABSTRACT:

Background

There are no approved pharmacotherapies for d-methamphetamine (METH) addiction and existing therapies have limited efficacy. Advances in using immunotherapeutic approaches for cocaine and nicotine addiction have stimulated interest in creating a similar approach for METH addiction. This study investigated whether active vaccination against METH could potentially attenuate responses to METH in vivo.

Methods

Male Sprague Dawley rats (n = 32) received a four-boost series with one of three candidate anti-METH vaccines (MH2[R], MH6, and MH7) or a control keyhole limpet hemocyanin conjugate vaccine. Effects of METH on rectal temperature and wheel activity at 27°C ambient temperature were determined. The most efficacious vaccine, MH6, was then contrasted with keyhole lim

SUBMITTER: Miller ML 

PROVIDER: S-EPMC3561477 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature