Physiological effects of housing density on C57BL/6J mice over a 9-month period.

ABSTRACT: The NRC has consistently recommended floor space for animals used in science and agriculture. For mice, the recommended floor space is 77.4 cm(2) (12 in(2)) for a 15- to 25-g mouse. The NRC noted that its recommendations were based on "best professional judgment" and encouraged alternatives that were data driven. As part of a continual effort of The Jackson Laboratory to ensure the health and well-being of production and research mice, while promoting cost-effective, state-of-the-art research, several density-driven studies have been conducted by lab researchers. The objectives of this study were to determine the effect of housing density on variables related to mouse physiology and air quality in cages and assess the value of specific measured variables in such studies. In the present stu

SUBMITTER: Paigen B 

PROVIDER: S-EPMC3561486 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature