Chitin-glucan fiber effects on oxidized low-density lipoprotein: a randomized controlled trial.

ABSTRACT:

Background/objectives

Elevated oxidized low-density lipoprotein (OxLDL) may promote inflammation, and is associated with increased risk of atherosclerotic coronary heart disease and worsening complications of diabetes mellitus. The primary objective of this study was to evaluate the efficacy of chitin-glucan (CG), alone and in combination with a potentially anti-inflammatory olive oil (OO) extract, for reducing OxLDL in subjects with borderline to high LDL cholesterol (LDL-C) levels.

Subjects/methods

This 6-week, randomized, double-blind, placebo-controlled study of a novel, insoluble fiber derived from the Aspergillus niger mycelium, CG, evaluated 130 subjects free of diabetes mellitus with fasting LDL-C 3.37-4.92 mmol/l and glucose ≤ 6.94 mmol/l. Participants were randomly

SUBMITTER: Bays HE 

PROVIDER: S-EPMC3561615 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature