Synthesis of biotinylated c-di-gmp and c-di-amp using click conjugation.

ABSTRACT: The biotinylated c-di-GMP and c-di-AMP conjugates 10a/b were synthesized by a straightforward set of procedures from standard, commercially available phosphoramidites. Their availability should allow isolation and characterization of new protein and RNA receptors for these key bacterial signaling molecules.

SUBMITTER: Gaffney BL 

PROVIDER: S-EPMC3561633 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature