The doublecortin-related gene zyg-8 is a microtubule organizer in Caenorhabditis elegans neurons.

ABSTRACT: Doublecortin-domain containing (DCDC) genes play key roles in the normal and pathological development of the human brain cortex. The origin of the cellular specialisation and the functional redundancy of these microtubule (MT)-associated proteins (MAPs), especially those of Doublecortin (DCX) and Doublecortin-like kinase (DCLKs) genes, is still unclear. The DCX domain has the ability to control MT architecture and bundling. However, the physiological significance of such properties is not fully understood. To address these issues, we sought post-mitotic roles for zyg-8, the sole representative of the DCX-DCLK subfamily of genes in C. elegans. Previously, zyg-8 has been shown to control anaphase-spindle positioning in one-cell stage embryos, but functions of the gene later in development ha

SUBMITTER: Bellanger JM 

PROVIDER: S-EPMC3561856 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature