Low level maternal smoking and infant birthweight reduction: genetic contributions of GSTT1 and GSTM1 polymorphisms.

ABSTRACT:

Background

Genetic susceptibility to tobacco smoke might modify the effect of smoking on pregnancy outcomes.

Methods

We conducted a case-control study of 543 women who delivered singleton live births in Kaunas (Lithuania), examining the association between low-level tobacco smoke exposure (mean: 4.8 cigarettes/day) during pregnancy, GSTT1 and GSTM1 polymorphisms and birthweight of the infant. Multiple linear-regression analysis was performed adjusting for gestational age, maternal education, family status, body mass index, blood pressure, and parity. Subsequently, we tested for the interaction effect of maternal smoking, GSTT1 and GSTM1 genes polymorphisms with birthweight by adding all the product terms in the regression models.

Results

The findings suggested a birth

SUBMITTER: Danileviciute A 

PROVIDER: S-EPMC3562502 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature