MMpred: functional miRNA--mRNA interaction analyses by miRNA expression prediction.

ABSTRACT:

Background

MicroRNA (miRNA) directed gene repression is an important mechanism of posttranscriptional regulation. Comprehensive analyses of how microRNA influence biological processes requires paired miRNA-mRNA expression datasets. However, a review of both GEO and ArrayExpress repositories revealed few such datasets, which was in stark contrast to the large number of messenger RNA (mRNA) only datasets. It is of interest that numerous primary miRNAs (precursors of microRNA) are known to be co-expressed with coding genes (host genes).

Results

We developed a miRNA-mRNA interaction analyses pipeline. The proposed solution is based on two miRNA expression prediction methods - a scaling function and a linear model. Additionally, miRNA-mRNA anti-correlation analyses are used to de

SUBMITTER: Stempor PA 

PROVIDER: S-EPMC3562514 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature