Immunogenetic study in Chinese population with ankylosing spondylitis: are there specific genes recently disclosed?

ABSTRACT:

Purpose

Ankylosing spondylitis (AS) is a systemic, autoimmune disease resulting in the destruction of the affected joints. Over the past 5 years, several new genes or genetic regions associated with AS have been identified in the Chinese population. This paper aims to discuss the major findings and related potential mechanisms of these studies in our population.

Recent findings

In recent years, due to the rapid advances in computational genetics and technology, there has been an increasing list of well-validated genes or genetic regions associated with AS susceptibility. So far, several genes or genetic regions have now been reported in the Han ethnic Chinese population, containing the major histocompatibility complex (MHC), ERAP1, IL-23R, 12q12, 2p15, 5q14.3, and so on. Dif

SUBMITTER: Zhai J 

PROVIDER: S-EPMC3562651 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature