Common variants in 8q24 are associated with risk for prostate cancer and tumor aggressiveness in men of European ancestry.

ABSTRACT:

Background

Recent whole genome association studies have independently identified multiple prostate cancer (PC) risk variants on 8q24. We have evaluated association of common variants in this region with PC susceptibility and tumor aggressiveness in a sample of European American men.

Methods

Forty-nine tagging SNPs including three previously reported significant variants (rs1447295, rs6983267, rs16901979) and seven variants in the 5' upstream region of the MYC proto-oncogene were tested for association with susceptibility to PC and tumor aggressiveness in 596 histologically verified PC cases and 567 ethnically matched controls.

Results

Significant associations with susceptibility to PC were found at 17 SNPs, four of which (rs1016342, rs1378897, rs871135, and rs6470517)

SUBMITTER: Pal P 

PROVIDER: S-EPMC3562713 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature