Incoherent feed-forward regulatory logic underpinning glucocorticoid receptor action.

ABSTRACT: The complexity and specificity of metazoan transcription are determined by combinatorial control of the composition and activity of regulatory complexes. To investigate the basis of this specificity, we focused on the glucocorticoid receptor (GR), a single regulatory factor that integrates multiple signals to give rise to many distinct patterns of expression. We measured the expression of a set of genes, each directly GR-regulated, but by different mechanisms in two cell lines. We varied ligand (dose, chemistry, and duration of treatment), GR (expression level and functionality), and a non-GR regulatory factor that commonly interacts with GR. Our study revealed distinct expression patterns within this set of genes, but all could be modeled by an incoherent feed-forward regulatory logic. Ce

SUBMITTER: Chen SH 

PROVIDER: S-EPMC3562826 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature